I have the same issue on my desktop hackintosh, which I recently (end of May 2017) upgraded from El Cap to Sierra. Mouse and trackpad preferences worked fine in El Cap, but now selecting them causes system prefs to crash. If I turn off the bluetooth Apple Magic Mouse, then I can open the mouse pref pane and configure a USB mouse that I have connected. That suggests it might be bluetooth issue, but my bluetooth keyboard pref pane works fine. To confirm, both the magic mouse and trackpad work perfectly, but it's impossible to change any settings.
I went directly to 10.12.5 from El Cap. I've tried lots of fixes, suck as deleting preference and cache files and replacing the sierra preference panes with those from El Cap (I have a clone backup of my El Cap install and used those). None of that has helped. I've done heaps of restarts and log ins too, of course.
I've attached the crash log in case any one can shed any light on the issue from that. It's mostly gibberish to me. The most important info, however, appears to be this:
Crashed Thread: 29 Dispatch queue: com.apple.coremedia.player.async.0x6000001146d0
Exception Type: EXC_BAD_ACCESS (SIGSEGV)
Exception Codes: KERN_INVALID_ADDRESS at 0x0000000000000010
Exception Note: EXC_CORPSE_NOTIFY
Btw, I have a refurb macbook bought recently and set up using migration assistant - so it has the same settings as the hackintosh. I can use the magic mouse with the macbook and system prefs doesn't crash.