Yes. In Big Sur with Apple VTD present from i/o Reg Explorer, 4x16GB of RAM are present, but there is no ethernet nor wifi services, even if the network configurations are removed or reset: Network interfaces are not even manually configurable with VTD enabled. Still using the modified Z390 BIOS: Z390DESI_modMC_01052021_0906_Rev_0xEA.F9i 2 and unflashed Thunderbolt.
With VTD disabled, everything in Big Sur with UAD and Pro Tools and Thunderbolt works as well as Mojave, but I would still use Mojave for recording. I edited that original post that had a terribly awkward and confusing last sentence.