Looks like there's lots of confusion when it comes to the sleep/wake issue. This does not, and has never, been an issue with a dedicated GPU. This is ONLY an issue if you're using the motherboard's integrated HD 530 graphics. Hope this clears that up. I'll keep my eyes peeled for a fix for this and will update my original post if I find one.
Does Clover need to be reinstalled after an update?
Generally, no, Clover doesn't need to be update before/after a macOS update. However, 10.12.4 required the latest version of Clover before the update, which ManMan provided here.No. But you might need to update Clover prior to updating macOS. I'm running Clover r4035 and the update was successful. According to Stork, if you're running an older version of Clover, "you may have to update Clover to r3994 or newer to achieve proper kext injection for the iMac17,1 kexts."
I upgraded from El Captain to Sierra, everything is ok except the audio. I even don't understand the guideline! Could anyone help me with this particular board using ALC1150?No Audio with RealtekALC.kext
Follow toleda's Sierra Desktop/Realtek Apple HDA Audio patch instructions HERE.