Last week I replaced an Radeon RX 580 with a Radeon RX 6650XT on my Z390 Designare that is now connected via DisplayPort to a
Cooler Master GP27U 4K mini-LED monitor with 160Hz refresh rate. Sonoma also supports Variable Refresh Rate (VRR) on this monitor (not with RX 580, which is why I've replaced it with 6650XT).
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There is no flicker or any other visual artifact. In fact, mini-LED with 576 local dimming zones is so amazing that I don't think I can go back. Even though there are 5K monitors out there, they would be a step down after this.