Some suggestions:
- Use Boot Argument shikigva=80 and reboot. Does the system still crash/reboot?
- Enable NVRAM so macOS can try and preserve the kernel panic information and display it on the next startup.
- If you have a bootable backup, please see if the crashes occur when booting off the backup.
- You may also attempt the Process of Elimination by performing a fresh installation of Catalina on a spare SSD and then installing/testing one app at a time to see if random crashes still occur.
- I think I've tried that shikigva value already, and ultimately ended up removing it completely. I have just tried switching over to your OpenCore setup (stock config) to see if that helps the issue at all. If it doesn't, I'll try 80 with it and see if that helps (unless you think I should just put 80 in it right now?).
- Native NVRam is enabled - but, I haven't been able to get any useful information back. The thing that's making this difficult is I'm not getting Kernel Panics. I'll generally be working in Ableton or on Chrome, and suddenly, the system just stops responding to user input. Audio/music I have playing continues playing, but it's almost like the mouse and keyboard just stop working. It's either that, or perhaps they are still working (as is the rest of the system), but the video card stops refreshing the screen? I don't know what it is at this point, but the system doesn't just hard-lock and stop working entirely. It seems to stops responding to input, and I have to manually reboot the computer. Upon rebooting, I haven't been able to find anything useful in Console. I'll try leaving it sit for a few minutes the next time I see it lock up to see if it does ultimately result in a Kernel Panic though, as I agree, that information would be helpful.
- Beyond that - New motherboard. New ram. New video card. New fresh install. This is a very purpose built system for audio production. There are not many programs beyond Ableton. It's intentionally lean to keep it light and keep problems at bay. I can attest to the hardware otherwise being stable under Windows when running games though, as it is a dual-boot system.
I think the real question is what I pointed out in my 2nd bulletpoint - is the system actually locking up, is the video card not refreshing the screen, or is the USB system dropping the keyboard/mouse out? If we can answer that, we might be able to shed some light on the actual issue.