You can certainly purchase a PCIe x4 card that accommodates one or more NVMe SSDs. As long as the card is advertised as being Mac-compatible, it should work in this system.
However, before you do that, how many SATA devices do you expect to connect?
- You can connect 3 SATA drives when both M2M and M2P are populated.
- If you need more internal SATA ports, you can always purchase something like this: https://www.amazon.com/dp/B01M0M5NV7/?tag=tonymacx86com-20
- This is Mac-compatible (there are several other similar products from different manufacturers) and uses a x1 PCIe slot.
On the Designare motherboard, the NVMe slots (M2M and M2P) do not share bandwidth with PCIe slots. They share bandwidth with SATA ports instead. So installing a card into the PCIe x4 slot will not reduce your M2M/M2P speeds.