Load Optimized Defaults after you've flashed the BIOS and before you make any other changes to it.
There is a "Load Defaults" tab in the lower central part of the window. Click on that and then click Apply.
Go to Boot Sequence and set the Boot List Option to UEFI. Under Advanced Boot Options leave the Legacy Option ROMs box unchecked unless you have an older graphics card without UEFI capability. For example a GTX 650 by Nvidia which is only Legacy capable. The GT 710 and all 10 series Pascal cards have UEFI capability. Also leave Legacy Option ROMs unchecked if you are using built in HD4000 graphics. Under System Configuration disable the Serial Port.
Secure Boot is disabled by default. SATA Operation should be set to AHCI by default. Check both of these and if they are set to anything else, change them. If you don't plan on ever booting your Dell remotely, change Integrated NIC to Enabled instead of Enabled w/PXE. If your CPU has HD4000 and you have no dedicated graphics, leave the Primary Display set to Auto. If you have installed an AMD or Nvidia card select that under Video -> Primary Display
Summary of BIOS Setting Changes
General
Boot Sequence -> Boot List Option -> UEFI
Advanced Boot Options -> Uncheck - Enable Legacy Option ROMs
System Configuration
Serial Port -> Disabled
Sata Operation -> AHCI
Integrated NIC -> Enabled
Video
Primary Display -> Auto (For HD4000)
Primary Display -> Nvidia or AMD HD Graphics (if using a graphics card)