Yes. I'm happily running 2 TB3 -> TB2 adapters (1 Apple and 1 Startech) with a TB2 -> Firewire adapter, and a TB2 LaCie Big5 RAID that has a Blackmagic Mini Monitor daisy chained off the back of it.
I am a video editor and Avid, Resolve, & Premiere all work happily with the RAID and passthrough video output. I run mostly on Windows 10 but bounce over to the Hack side if I need to use Autodesk Flame.
There's still no hot swapping of TB devices, but I can swap out Firewire drives quite happily.
On the odd occasion the TB devices won't be detected at boot up, but they usually reappear after a reboot. Or, on even rarer occasions, two.
If you want specifics on my build, tell me what you want, and I'll get that info for you. My system was configured by someone else far more knowledgeable than I!