This is very dependent on the board and firmware. I personally experienced problems with BIOS upgrade on my ProArt Creator, but other owners did not. This is not a macOS issue, but an Asus issue. Besides that, my Alder Lake system has been very reliable. I have a free 3 month subscription to Adobe Creative Suite (Asus promotion) so I’ve been lightly experimenting with those apps, all of which work just fine. If your X299 system is both fast and stable, perhaps it would be best to upgrade directly to Apple Silicon. The only reason I haven’t jumped on the Mac Studio is because I purchased a 14” MacBook Pro (with M1 Max) last year. So my mobile computing is now on Apple Silicon and my desktop computing is on this Z690 system.