After installing Sierra 10.12.2, I was struggling to get Nvidia drivers working with a $300 Nvidia 980 GPU. I changed my plans and decided to try an AMD card. I put in a Gigabyte 7970 card (GIGABYTE Radeon HD 7970 DirectX 11 GV-R797OC-3GD 3GB 384-Bit GDDR5 REV 2.1 PCI Express 3.0 x16 HDCP Ready CrossFireX.)
I got this card for $100 on Ebay. The card was "plug-and-play" and was recognized over my DVI port immediately at boot with no fooling around and it runs my DELL U2413 @ 1920 x 1200 @ 60 Hz and Pixel Depth:30-Bit Color.
This was a very easy install, it just works. I don't need 4K or 5K. And this card rips through photoshop and video editing. GPU scores with Geekbench open CL 106,389 which is ample for my needs -- I edit 1080 video and do graphics -- no gaming here. I don't know if all 7970 cards are equally good, other manufacturers may vary but so far this is a great $100 solution.
Wake from sleep? I never sleep my system anyway. I have "put hard drives to sleep when possible" enabled in preferences. Other than that, my computer is off -- or on.