I tried for hours again. The only clue I have is that in graphics section of sierra's system report, it says the rx480 ( in pcie slot 2) is in a 1X slot. There is a hd5750 in slot 1 as a helper card ( x16). All I can figure is that my mb (asus x99 pro usb 3.1) changes the slots according to the CPU lanes. My cpu is a 6800k, which is 28 lanes. this should change the slot 2 to x8 and x8 would work, but for some reason it makes the 2nd pcie slot I can use 1X, which the manual says can be changed to 4X. This I read later. I don't think the rx480 is gonna work on 4X. I might give it a last try again. It's a 4 slot motherboard, so 1x16 slot and 3x4 slots for xfire, though there isn't enough room for double wide cards, so whats the point of making 4 xfire slots? Have to hope they make rx480 a native card in a future release