This sounded like hocus pocus to me but I tried it anyway, just to debunk this fairy tale... Sure enough, I couldn't even boot in to Finder. I had to boot in safe mode and reinstall the web drivers. After reinstalling with SIP enabled, it still lagged like crazy.
When I've upgrade to 10.13.3 - I've encounter the same issue with 156 driver - I had SIP partially disabled. So I went to 106 driver and the lag disappeared. Yesterday I saw that a lot of people were telling that if you install the drivers with SIP f enabled - the lag will disappear. So as I stated before:
I've removed NVIDA + CUDA driver and installed them with SIP fully enabled ( 0x0 ).
All is working good now. I don't know if it does matter, but I have lilu + fake kext in the Other folder and two other for audio and lan.
Edit 1: I also updated Clover to the latest version available and I use the OsxAptioFix3Drv !