The standard update worked for me, but the combo update did not.
I tried the combo update in several ways with no success - I got kernel panics whatever I tried.
The most interesting failure was this: I have two 10.6.7 boot disks that are mirror images of one another, maintained using Carbon Copy Cloner (the best piece of software that a hackintosh owner can own). When I booted from one disk, and then tried to install the 10.6.8 combo to the second disk, the install failed and I got a message to "contact the vendor".
I restored the second disk, and then tried the same install method using the standard update, and it worked with no issues. Had to update the audio using Multibeast, but no big deal.
I'll run it today, but so far it seems stable.