piggy backing off what RastaFeri wrote above, here's what I'm doing to prevent the freeze. The oddest thing about all this is that in 10.7 and 10.7.1 the Fermi Freeze was completely gone on my setup (with a GTX460). I tried rolling back drivers, but that didn't work. Anyhow, onto the 'fix' -
Download the attached program and install the latest CUDA drivers to your computer. Once launched, move the application's slider so you're generating ~150 triangles. You can now either minimize the program, move it to a different space, or, even better, hide it by using Command H. Since there's no dock icon it's almost completely transparent once this is done. This also takes up scant resources - on my GTX460 (which i overclocked with a modded BIOS) this raises the card's temperature roughly 2C. by comparison, watching a GPU-accelerated video will push it up by ~15C.
As an added bonus, since this is pulling your card out of the lowest clock settings, you should notice a much faster UI if you hadn't already edited your AGPM.
I've yet to crash my system using this, meanwhile I'll usually have a couple of hours before a freeze without it. This works on both Lion and Snow Leopard.