Prior to building this Hackintosh, I was running ProTools v9 on my Mac Pro (5,1). This Hackintosh has forced me to upgrade ProTools to v12, because I'm running 10.10.5. Interestingly, I can't get ProTools to see my 003 Rack (legit pro-tools hardware), but it sees my MOTU 424 card just fine. The system sees the 003 Rack, just not ProTools. I'm unsure if that is due to the new version of ProTools, or the fact that this is a Hackintosh.
My Audio interfaces are either Protools 003 Rack, or a Motu 424 card, coupled with a Motu 2408 MKIII and a Motu 2408 MKII.
Do you have multiple dongles? I have so many systems in my studio, and so many licences, I actually have three dongles plugged into this one machine. I found that I couldn't launch the E-LICENSER software if I had them plugged into the same USB port via a hub. They each needed their own port.
I've actually gone back to stock clock speeds for everything. System is still randomly rebooting 2-3 times per hour while working. I've never had it randomly reboot like this during stress testing. Because it just "reboots" it doesn't even give me a crash log to look at.