So I did a lot of testing and here's my best boot.plist for the Sapphire HD 6450 1GB DDR3, model #10322L.
Chimera 1.8 with DSDT and ROM from techpowerup in /Extra/, iMac12,2 in smbios.
<key>GraphicsEnabler</key>
<string>Yes</string>
<key>UseAtiROM</key>
<string>Yes</string>
<key>AtiConfig</key>
<string>Juncus</string>
Duckweed also worked, but Juncus produced the best benchmarks with cinebench. With Juncus the display was able to sleep and video motion was noticeably smoother. Benchmarks rose 3 FPS when using the ROM. PciRoot didn't really make a difference in benchmarks or my viewing.
Accurately detected in System Profiler, display sleeps and wakes properly (it didn't with Duckweed) and all of the ports work. Sorry, I didn't get a chance to test HDMI.
Cinebench results: 17.46
I didn't notice any of the problems I had with dropped frames using Juncus that I previously had had with Duckweed.
I still had issues with the color, even after a lot of recalibration, but this is likely just my taste. My girlfriend also thought the color was oversaturated as well, and given that she rarely notices the difference beween a 480p broadcast rip and a 1080p Blu-Ray rip that probably says something - she was even disappointed and suggest I buy a more expensive card, a relationship-situation that is unheard of. This may also be the reason why design and graphics professionals prefer nvidia, but the 6450 does perform better on almost every video benchmark done by reviewers than a similarly priced GT 220/520 or a GT 430/440 - if my memory is correct it rivals a GTX 460 that costs up to 3.5 times as much. So, if you do a lot of encoding the 6450 is definitely the better card. After research from reviews and forums, I only noticed a handful of commentators complaining about Radeon color accuracy, so it may just be me. I also wanted to try MacPro3,1 in the smbios to see if benchmarks changed, but got too excited when my other card came, and since my scores were better than most other reviews of this card I chose not to bother.
For my needs I picked up a passive ASUS GT 440, and after a few quick tests I can say it's video processing is better suited towards my tastes. Worked OOB with GE=Y and MacMan's OpenCL edits installed with MultiBeast. The Quadro driver used for Fermi cards said it was incompatible but I might try adding the device ID to the kext and see if that makes a difference later. Watching my 46GB copy of Midnight In Paris with my TV calibrated as I had previously calibrated (using a friend's calibrator and three high-end reference sources) the picture was significantly more accurate - I could see shadows and splotches and facial hair where I used to see glowy, red flesh, and the colors look like sunlight is hitting objects rather than the objects producing light themselves. The motion was better as well, but not as good as my GTX 470. Cinebench scored 29.05, but this card does cost $15 more, $25-35 without the rebate, for a passive version. If I have time I'll try and see if screenshots can capture the difference - it really is night and day. But, then again, some people prefer glossy to matte, led to plasma, and so on, but the accuracy and the benchmarks suggest to me that the GT 430/440 are the better buy for the HTPC and low-end markets by a long shot.