Aptio (originally from AMI) is a BIOS firmware, based on the UEFI Specifications and the Intel Platform Innovation Framework for EFI. Aptio helps with firmware portability and extensibility to various platforms like in OS X or macOS. Aptio can be expanded using a variety of drivers, development tools, support utilities and pre-boot application solutions.
AptioFix2Drv is one such drivers used to modify Aptio behavior in booting from BIOS. If incorrect OsxAptioFixDrv.efi is launched from CLOVER/drivers64UEFI folder, the boot disk that contains that CLOVER, hangs /crashes before reaching CBM screen. In some cases if it makes it to CBM it can fail later during boot to the target screen.
I think of OsxAptioFixDrv as a BIOS fixer-upper for Hackintosh UEFI booting using the CLOVER Bootloader modifying Tool to boot from BIOS. Like any other hackintosh software, frequent modification is the rule as different users buy different MoBo/CPU/Graphics for their build and one driver cannot do the work in all of them. Hence the trial and error method when problem occurs.
It is not a good idea to put all known OsxAptioFixDrv.efi s to be placed inside /EFI/CLOVER/drivers64UEFI hoping something will help! That will only cause the problem to repeat in subsequent boots. When you find one is causing the error, remove that and replace with a modified one and reboot and try.