Hi tog,
The Fortress is better suited for passive cooling with its vertical airflow (heat goes up). I want one too.
As far as I know, you can go fanless removing all the useless fan holders, and using a massive cooler made for that purpose, like the Thermalright HR02, which is heavy with spaced fins. I think the Scythe Ninja 3 should do the trick too, but I'm not sure it fits (the HR02 does, but be careful with the DDR3 heatspreaders).
Depending where you live, it would be a nice idea to monitor the temps with iStat Menu. In summer, fanless is clearly a bad idea for hardware.
About the GPU, Duke Nukem is not a very demanding game, and you'll be able to play with low settings, 720p resolution or older games like WoW, but try Crysis or GTA4 and your GFX will melt. You may experience graphic bugs in a matter of minutes, due to temperature going well over 110°C on the VRM.
The thing is: you don't need to go fanless to be silent. A good fan like Noctua NF-S12 (not the NF-P12), Scythe Kama flow at 500rpm are completely silent. They don't move much air, but it's enough to lower the temps of a non OC'ed CPU/GPU.
Plus, airflow "hides" electronic buzzes and high-pitched HDD scratches that are much more annoying. A totally silent computer would cost something like 300$ more than a standard one, with a passive PSU, high-end coolers, acoustic foam for vibrations, an SSD, thick steel or thicker aluminum case, and so on.