Does an AMD Radeon RX 580 work with my computer specs?

[Luna]

Title explains it all.

 

[Jamesbond007]

Title explains it all.

Sure. It should work. Your motherboard together with the CPU support PCIe 4 which will work with PCIe 4 and PCIe 3 graphics cards including the RX 580.

 

[Luna]

Sure. It should work. Your motherboard together with the CPU support PCIe 4 which will work with PCIe 4 and PCIe 3 graphics cards including the RX 580.

What macOS versions will it be compatible on?

 

[trs96]

What macOS versions will it be compatible on?

High Sierra through Sonoma. The Mac Pro 7,1 (2019) originally shipped with a workstation variant of the RX 580 so it's supported.