It is possible. I just installed 10.10.4 last night and finally got it running this morning. Using the unibeast method it is pretty simple. My specs are: R3G, i7@950, 12GB Mushkin Ram, 2@GTX 580, 2@Crucial MX100 512GB not raid. With MAc OS as main drive boot in to the unibeast installer. NO PCIRootUID=1 needed. Thats where I keept making mistakes.
-V (not necessary) GraphicsEnabler=YES (GTX 4xx, 5xx cards) and npci=0x2000. This is all that is needed to boot. On new SSD's you will need to do the "boot0:error" fix described on the forum after install. Then all will be good.
I still have no sound but I have dealt with that before and USB-3 I don't believe is working but all else works well.
Good Luck!
PS: There is a good DSDT floating on one of the other forums that I used (insanlymac I think). Seems to be working well