I wanted to recommend a PCIe card that works in Mojave and Big Sur which supports 4 eSATA ports and port multiplier enclosures for up to 20 connected drives:
Ableconn PEX-SA134 4-Port card
It wasn't cheap ($134), but it seems reliable. I'm able to hot swap drives in my SeriTek/2eEN4 4-bay...
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