AVX is heavily used in pro apps like Cinema 4D. macOS does use AVX, but I can't pinpoint exactly how much. Apple hooks into Intel features all the time since it's the only CPU macOS works with officially, ie iGPU/QuickSync was heavily used by native Apple apps like FCPX, but I think now they moved away from it and hook into Metal which can then hook into Intel iGPU or AMD Compute Units.
Run CineBench R15 or a full version of C4D and render a heavy scene and you will see it push AVX really hard.
My current OC settings are:
x44 on All Cores
-5 AVX on both
CPU Input Voltage is set to Auto
XMP is on (GSkill 3200MHz 128GB)
Under 80c (usually 79c on full load)
Throttle is set to 84c per Intel TJunction for 9980XE. It never reaches that even on extreme full load.
All works well, zero crashes, no errors, slowdowns etc. Before when I had AVX to default -0/-0 (or the one from KGPs original guide) it was a tad unstable and I noticed microstutters sometimes. And the CPU was being pushed too far with OC on. Now it's a really good balance.
It would be interesting if anyone was curious enough to look at the iMac Pro or future Mac Pro firmware dumps to see what exactly Apple does with AVX or any other Intel hooks. I think this would make Hackintoshes more perfect and stable if we figure that out.