SUCCESS! High Sierra 10.13.3 // Focusrite Clarett Thunderbolt 3

[soapmak3r]

@soapmak3r it is safe to delete these files; they will be recreated upon reboot. If you are at all concerned about some of your audio settings, you can zip up those files as a backup and replace them if anything goes awry.

I appreciate the help.
I checked, but that folder doesn't appear to exist, and in the library/preferences folder, those files don't seem to exist either.

Only com.apple.audio.AudioMIDISetup.plist and com.apple.audio.InfoHelper.plist

The TB3 port is functioning as USB-C with a USB-C USB/HDMI Hub, but the TB functionality is not being detected with my audio interface and MacOS is not showing TB drivers as being loaded. Could it be something to do with how I configured things with Multibeast for USB?