Update to my earlier post:
It seems to be a localised problem if devices are plugged into certain USB2 ports only, using different ones make the issues go away (there are 12 or more on this mobo). I presume one or more controllers is the root of the problem and I can hopefully identify exactly...
I have a very similar system on which I have installed 10.13.5, using your EFI folder as a template its working well with the notable exception of a USB triggered kernel panic on shutdown or reboot (this post is similar, I have attached the error output from my system - the offending devices...
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