Its really, really strange because im using audio interface of my AudioTecnica USB microphone with ZERO problems. For me it looks like its a hardware combination problem with Focusrite, maybe 5700xt audio output. I will use onboard card until solve this since i dont record too much...
You managed to solve this? i got EXACTLY same problems as you (z390 aorus ultra/i7 9700k/radeon 5700 xt/evo 970/focusrite 2i2/latest catalina/opencore 6/latest mobo firmware) for music production, built in soundcard works perfect. I manually recreated all SDTS to match my mobo, remaped all usb...
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