Hi, my UP2715K works fine at 5k with 10.12.1.
When I boot, I can leave it on, as long as I power cycle once I get at login screen (the system detects it as two different monitor before I switch it off and on).
The only issue is with sleep. If I switch off the monitor BEFORE putting the system to sleep (via keystroke), it wakes up fine. If the system goes to sleep while the monitor is on, it reboots when trying to wake up.
A few notes on my setup (hardware in signature):
I set nvda_drv=1 nv_spanmodepolicy=1 via Clover Configurator. I tried to add them directly in NVRAM but I got an error. I'm not sure if it depends on the emulated NVRAM I had to install (see
https://www.tonymacx86.com/threads/solving-nvidia-driver-install-loading-problems.161256/ problem 6) or SIP enabled (I haven't tried to disable it yet).
Thanks!