Here's some info that might or might not be helpful, if you guys are running UEFI mobos.
[begin irrelevant stuff]
I've got two identical systems, both of which are i7-3770s on Gigabyte Z77X-UP5 mobos equipped with Quadro 2000s, and both running 10.8.3.
One of the two systems has experiencing odd problems whereby Adobe CS6 (pretty much any app in the suite) would at random times hang the system. I could move the mouse around, but wouldn't get any response from anything otherwise and had no option but to hit the reset button. At first I thought CS6 was at fault so I did a clean install, but the problem persisted.
The second system had been running fine in the two months since I updated to 10.8.3, and in fact I had been doing some very beefy projects in CS6 on it, and it handled them like a champ. A couple weeks ago I wanted to install Win7 on a second HDD of this system, and I set changed several BIOS functions from "UEFI" to "Legacy Only" before doing so. Installed Win7, did what I needed to do, then went back to OSX.
Shortly after, this system started developing the same behavior as the first system.
[end irrelevant stuff]
A few bits of info I googled elsewhere led me to a hunch that maybe there was something regarding the BIOS or UEFI that could affect it. I checked the first machine, and sure enough "Display Boot Option Control" was set to "Legacy Only". I set this to "UEFI First" (and just for good measure, I did the same for "Boot Mode Selection", "Storage Boot Option", and "Other PCI Device ROM Priority"). I've only been testing for half an hour, but so far so good. Too early to say if it fixed the problem yet, but something worth checking.