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Upgrade advice for x99 MB

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If you plan to install Monterey 12.1+, so the RX 6600 will work you would be advised to find a guide for an X99 board that shows how it can be done.

Here is a link to a guide for an Asus X99 Deluxe II running macOS Monterey created by CaseySJ -

https://www.tonymacx86.com/threads/monterey-public-beta-on-asus-x99-deluxe-ii.314207/

That would probably be a good place to start, even if the guide is for a different motherboard and CPU. The processes used should be the same for getting Monterey running on your system. I am sure others with X99 systems will have used this as a base to work from.

There also these two Threads, which are more a success story than a guide, the second of the two the OP is using a similar Asus X99 motherboard:


 
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