I took a leap of faith and updated the UEFI BIOS on my GA-Z68MA-D2H-B3 this morning (to the new U1c version), and I can't really see anything different other than a few menus changed in the BIOS setup. Everything still works as it did before.
I did have some trouble getting the new BIOS updated, since as it turns out, you can't use the DOS utility that downloads with the BIOS update to go from one UEFI BIOS version to another (you can only use it to go from legacy BIOS to UEFI). You have to use the onboard Q-Flash utility to update the UEFI BIOS, and it apparently only recognizes EFI drives (so it couldn't see my USB flash drive). I ended up having to boot back into Mac OS X, mount the EFI partition of my boot drive and copy the BIOS update to that partition, which is the only one Q-Flash could see.