Had no idea until now, thanks for the info! Reading about it, seems time will tell. The spec sheet on the website specifically says there are 2x M.2 (Key-M) which I'm sure most users would want to reserve for a couple M.2 SSDs, and the Wi-Fi/BT module is 1x M.2 (Key-E). On its face, that sounds like the same port we've been using. M.2 (Key-E) accepts the standard A/E key adapter for Broadcom modules ubiquitous in Hackintoshs.
For what it's worth, our mobo, the ASRock Z390 Phantom Gaming ITX/ac, says the Wi-Fi/BT module is an Intel CNVi M.2 (Key-E) vertical port. I can confirm, as I'm sure you can, that it works perfectly fine with the standard Hackintosh adapter and Broadcom units!
More important is whether the port is "locked" or not: For us the installation is as simple as plug-and-play. Considering the market segment I'm inclined to think the MSI Z490I would be the same unlocked port style implementation rather than locked in the BIOS or elsewhere to work exclusively with Intel CNVi cards.
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TL;DR: CNVi sounds more like a M.2 (Key-E)-compliant, and reliant, protocol rather than a whole new proprietary connector. A new WiFi/BT proprietary connector would be awful for the Hackintosh community, but based on mobo's spec sheets, I don't think CNVi implements a new connector.