I suggest you start with minimal number of disks "one" when installing High Sierra, I never installed High Sierra from scratch; so not possible to provide much help, but I can confirm that HS runs without issues.
Well one issue - occasional I see an issues with both monitors showing squares while resuming from sleep, I then press ESC and wait for screens to turn black, then i move mouse and screens resets and initialises. I believe nVidia Web drives somehow does not reset correctly on resume. NOTE: This does not happen if only Screens is a sleep