GA-Z170X-UD5 TH
Update:
USB 2.0 and 3.0 ports working flawlessly, I can share my patch if anyone wants. Do need to disable some of the unused ports to fit under the 15-port limit. Seems like the recs are not to use the raise port limiter patch long term. I disabled the onboard ports I wasn't using and some of the 2.0 ports. I don't know if the Thunderbolt type C ports are working or not as I have no devices to test them with.
Fixed the issue with WD drive. was formatted as exfat and I think something got corrupt as I hear is common with exfat so OS X was reading it as FAT. Reformatted to mac's file system and no issues.
iMessanger - able to log in and receive but can't send. Going to try the 14,2 profile again. In messing around to get the USB ports working I switched to MacPro 5,2 but I doubt that did anything useful.