@Slickademo,
I just installed a Radeon Pro WX 4100 in one of my systems (see Media Mac build in my sig) and it works very well.
Just needed to update to latest Lilu + WhatEverGreen and configure IGPU as headless.
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If space is tight and you need a single slot, low profile AMD GPU it does the job, no compatibility issues as its natively supported and for such a small and dare I say "cute" little GPU it works surprising well.
Primary use for me is for improving video playback on my Media Mac HTPC.
It also works very well the new WhatEverGreen AMD DRM enabling feature as detailed here :-
@ALL, December 2nd 2019 Note: Not applicable if you are using the iMacPro1,1 SMBIOS. The developers of Lilu and WhatEverGreen have now publicly released Lilu 1.4.0 and WEG 1.3.5 which includes a new method for enabling Native MacOS DRM playback on most systems as long as it has a AMD GPU...
www.tonymacx86.com
Of course if playing triple A games is a priority (which it is not for me) then its not the card for you.
Having said that it does run basic games well, way better than the Intel IGPU.
Runs cool and the fan makes no sound so good for a HTPC which is what i'm using it for.
I was super lucky and managed to snag one for a very low price on eBay.
If you want a low power no fuss GPU for supporting basic MacOS features then I can highly recommend the WX 4100.
Cheers
Jay