I Have the same board , everything works fine , I gave up on the Internal Audio
it just wont work no matter what, display port and hdmi audio works fine
but i have my pc connected to an old receiver so i need internal 3.5mm jack
so instead i disable the Audio from within BIOS and installed a Creative Rx5 sound card that i had laying around, i put it in a pcie x1 slot and with a few kexts works perfectly fine im sure is way better than the built-in audio , im sure you know Creative (Soundblaster) cards are not supported in OSx ,also i gave up on the Thunderbolt 3 i bought 2 cards and could not get the BIOS to detect them , i even contacted MSI and gave me a few screenshots but still no luck, and then quietly they removed all z490 motherboards from the compatibility list , shame on MSI, what is the purpose of having a thunderbolt header if MSIs own thunderbolt cards will not work, oh well
back to topic
intel i5
32gb ram
2 nvmes
bluetooth wifi card BCM94360CS2 pci-e x1
creative Rx5 pci-e x1
msi RX580
audio works
sleep works
wifi and bluetooth work no kexts , works in windows too with Apple drivers
Macos big sur
opencore 0.6.3
i can say it is almost perfect no issues as of right now