Everything works again. It were settings in VBM that stopped macOS from booting. I'll try later which settings won't work bus I'm nog inside Big Sur. Only thing now is fixing the slow boot. @serdeliuk said it may be debug mode. I'll see what is taking macOS so long. I do have Some ideas. Disk2s1s5 orso gives during startup an error: device is not readable or something like that. That disk is the main disk of macOS, the disk itself. Can't Mount that because it is not a partition.
Best way to get rid of all VirtualBiosMod settings is to go to BIOS and load BIOS defaults or optimized ones, this will bring back all settings to factory defaults, including startup sound so bios settings needs to be readjusted accordingly
In VBM there's that option. Click F to cycle through memory sizes. If on 2048MB, HID LEGACY SHIM 2 or VoodooGPIOCannonLakeH: getting GPIO data. That last is from VoodooI2C getting the data of the TouchPad. So if I select more VRAM (at least I think it is, laptop's not on) it can't load TouchPad? I also found its about videocard which does make very good sense. If 2048MB, macOS is stuck at Intel videocard.