Going Bald
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@absurdio,
I have yet to see a commercial board with more than one true PCIe NVMe slot. If the board has additional M.2 slots, they are all, as jay monkey says, controlled off of the PCH and will disable at least one SATA port. Suggest if you want to have additional NVMe fast SSDs, get a PCIex4 to NVMe slot adapter and install it in a spare PCIe slot. If you wind up using the second PCIex16 slot and the UEFI allows you can then set that slot for x4 operation. Note that for each additional PCIe lane you use for drives you will decrease the lanes available to your graphics card in multiple of 4 - i.e. you have 20 lanes and 3 NVMe drives x 4 lanes each leaves you only 8 lanes for the GPU. This may or may not matter to you in the normal course of usage if you need the transfer rate of the NVMe SSD more than you need the faster GPU.
I have yet to see a commercial board with more than one true PCIe NVMe slot. If the board has additional M.2 slots, they are all, as jay monkey says, controlled off of the PCH and will disable at least one SATA port. Suggest if you want to have additional NVMe fast SSDs, get a PCIex4 to NVMe slot adapter and install it in a spare PCIe slot. If you wind up using the second PCIex16 slot and the UEFI allows you can then set that slot for x4 operation. Note that for each additional PCIe lane you use for drives you will decrease the lanes available to your graphics card in multiple of 4 - i.e. you have 20 lanes and 3 NVMe drives x 4 lanes each leaves you only 8 lanes for the GPU. This may or may not matter to you in the normal course of usage if you need the transfer rate of the NVMe SSD more than you need the faster GPU.