Make sure you followed all install instructions. Make sure you are booting from your hard disk, not the Unibeast USB.
Because it sounds like kernel cache issue, with incompatible set of kexts installed to /S/L/E. Monitor system.log in Console while rebuilding kernel cache to look for errors.
Code:
[FONT=Helvetica]Jul 22 18:51:39 Bastis-Mac-Pro.local authexec[303]: executing /usr/sbin/kextcache[/FONT][FONT=Helvetica]Jul 22 18:51:40 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleIntelHD4000Graphics.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:40 Bastis-Mac-Pro kernel[0]: Resetting IOCatalogue.[/FONT]
[FONT=Helvetica]Jul 22 18:51:40 Bastis-Mac-Pro.local com.apple.kextcache[302]: / locked; waiting for lock.[/FONT]
[FONT=Helvetica]Jul 22 18:51:40 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleIntelHD4000Graphics failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:40 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleHDAController.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:40 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleHDAController failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUpstreamUserClient.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUpstreamUserClient failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load IOBluetoothSerialManager.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.iokit.IOBluetoothSerialManager failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleSMCPDRC.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleSMCPDRC failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleWWANSupport1.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleWWANSupport1 failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleWWANSupport1.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleWWANSupport1 failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load IOUserEthernet.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.iokit.IOUserEthernet failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUSBCDCWCM.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUSBCDCWCM failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUSBCDCACMControl.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUSBCDCACMControl failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUSBCDCACMData.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUSBCDCACMData failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUSBCDCDMM.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUSBCDCDMM failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUSBCDCECMData.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUSBCDCECMData failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:41 Bastis-Mac-Pro.local com.apple.kextd[11]: Can't load AppleUSBCDCECMData.kext - ineligible during safe boot.[/FONT]
[FONT=Helvetica]Jul 22 18:51:42 Bastis-Mac-Pro.local com.apple.kextd[11]: Load com.apple.driver.AppleUSBCDCECMData failed; removing personalities from kernel.[/FONT]
[FONT=Helvetica]Jul 22 18:51:47 Bastis-Mac-Pro.local talagent[169]: PersistentUI: CSBackupSetItemExcluded() failed with OSStatus -61[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextcache[297]: Source item //System/Library/Extensions has changed since starting; not saving cache file[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextcache[296]: Child process /usr/sbin/kextcache[297] exited with status 4.[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextcache[296]: Error 107 rebuilding /System/Library/Caches/com.apple.kext.caches/Startup/kernelcache.[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextd[11]: kextcache error while updating / (error count: 1)[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextcache[298]: Lock acquired; proceeding.[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextd[11]: async child pid 296 exited with status 4[/FONT]
[FONT=Helvetica]Jul 22 18:52:05 Bastis-Mac-Pro.local com.apple.kextcache[298]: rebuilding /System/Library/Caches/com.apple.kext.caches/Startup/kernelcache[/FONT]
[FONT=Helvetica]Jul 22 18:52:12 Bastis-Mac-Pro.local com.apple.kextcache[305]: / locked; waiting for lock.[/FONT]
[FONT=Helvetica]Jul 22 18:52:43 Bastis-Mac-Pro.local com.apple.kextcache[304]: Created prelinked kernel //System/Library/Caches/com.apple.kext.caches/Startup/kernelcache.[/FONT]
[FONT=Helvetica]Jul 22 18:52:43 Bastis-Mac-Pro.local com.apple.kextcache[298]: /: no supported helper partitions to update.[/FONT]
[FONT=Helvetica]Jul 22 18:52:43 Bastis-Mac-Pro.local com.apple.kextcache[302]: Lock acquired; proceeding.[/FONT]
[FONT=Helvetica]Jul 22 18:52:43 Bastis-Mac-Pro.local com.apple.kextcache[302]: /: no supported helper partitions to update.[/FONT]
[FONT=Helvetica]Jul 22 18:52:43 Bastis-Mac-Pro.local com.apple.kextcache[305]: Lock acquired; proceeding.[/FONT]
[FONT=Helvetica]Jul 22 18:52:43 Bastis-Mac-Pro.local com.apple.kextcache[305]: /: no supported helper partitions to update.
[/FONT]
What kind of USB ports? USB2 or USB3? If USB3, have you tried GenericUSBXHCI.kext
Installed it per Multibeast but also no USB. The Laptop has 2x USB 3.0 Ports