Same issue here, although I am using an actual 2009 Mac Pro - not a Hackintosh. I just bought this ASUS GTX 1060 6GB and have been running it Mac OSX and - intensively - under Windows gaming, and it has been fine........
But, when I wake my Mac up from sleep (under the latest version of Sierra), I have the same issue. Applications within my screen glitch and flash; UI features are slow, choppy, and buggy; and it can only be fixed if I do either of the following: restart my Mac or log out and then log back in again. I haven't tried Hot Corners, but I'll test it out.
So far, I have tested this with both versions of the driver and have seen the same nasty results. I hope Nvidia works this out!