if you are using the f20 bios, i think you need to edit one of the generate SSDT files. F20 bios handles the USB differently.
see post: https://www.tonymacx86.com/threads/guide-sierra-on-the-ga-z170x-ud3.202296/page-17#post-1406742
with the first card i had to set it as internal, are else the bluetooth would wake the pc instant after sleep.
the new second card it doesn't matter, i currently have it set to external and it still works, wake using mouse/keyboard etc...