Nineniner, I haven't yet dug around with kexts or my config, but I have found a workaround. Changing Energy Saver settings to disable sleep mode solved the issue, so I at least know that therein lies the problem.
Wanted to submit this post for reference. Successfully installed High Sierra 10.13.5 on a pre-built Dell Optiplex XE2 with an added graphics card (Nvidia GT640). I've successfully got the following installed and working.
1. Operating System (obviously)
2. Audio (front and rear panel)
3. USB...
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