I don't think so.
I have TWO Dell 530's : one modded for Xeon E5450 with a modified BIOS and one with Q9300 CPU with stock BIOS.
I can boot the Installer USB on both systems and Disk Utility finds all my SATA drives.
I never had joy with Unibeast with the Dell 530 and to be honest I never use it for installs - not flexible enough for me.
In fact as a test, I just created a Unibeast USB Installer using the latest version and booted from it. It two minutes, yes two minutes to get to Clover Menu. On start boot, it takes further 3 minutes to display the clover ++++++++++++++++++++++. and then another two minutes to start seeing the verbose boot messages and hang - never gets to the macOS Installer. This happens on both systems.
- So I erased the same USB with disk utility.
- Used Clover Installer to install Clover on the EFI partition of the USB and selected
boot0af as the boot strap loader.
- Copied the DSDT.AML, config.plist, FakeSMC & networking kexts to rights places on EFI.
- Used the command line '
sudo "/Applications/Install macOS High Sierra.app/Contents/Resources/createinstallmedia" --volume /Volumes/install_osx --nointeraction' to build the USB installer (install_osx is the name of the USB).
- Booted the USB: 10 secs to Clover menu. Start boot and 20 secs to Clover ++++++++++++++++ display and verbose output.
- within a minute, Installer up and Disk Utility sees all my SATA drives.
I suggest you try the same. Here's
@RehabMan's
guide to create an Installer. It's for laptops but you'll understand the basic steps (I showed above) that can be applied to desktops.
Attached is my USB Installer EFI partition content. I have an Nvidia GT240 graphics card so the DSDT.aml has GFX0 device entry for this card and config.plist sets Inject Nvidia = Yes. If you use it, you have to modify the DSDT for your GPU if it's not Nvidia.
EDIT: Added a dump of mine folder containing the modded BIOS. Launch.bat is what you run from DOS-BOOT - USE AT YOUR OWN RISK.