Skylake builds seem to be working okay. My 4790K build with RX480 crashes FCPX 10.3+ if I have Intel injected. I have to remove Intel injection on mine, and FCPX 10.3+ works fine. However, I have no sleep without Intel injection (monitors only sleep, system keeps running). Also suffer from slow boot/shutdown. Sleep works perfect, and bootup/shutdown are very fast as they should be when Inject Intel is checked.
Slow boot time is not that big of an issue, but I really relied on sleep a lot before (shut down overnight only), but now I shut down a restart a few times a day as needed, when I know I'll be stepping away for a while.